First COVID-19 vaccine shows promise ahead of large U.S. trial

A COVID-19 vaccine tested on 45 healthy adults in March by the National Institutes of Health and Moderna found a promising immune system boost response from the participants, the researchers reported in The New England Journal of Medicine.

COVID-19 vaccineLauran Neergaard for The Associated Press:

The first COVID-19 vaccine tested in the U.S. revved up people’s immune systems just the way scientists had hoped, researchers reported Tuesday — as the shots are poised to begin key final testing.

“No matter how you slice this, this is good news,” Dr. Anthony Fauci, the U.S. government’s top infectious disease expert, told The Associated Press.

The experimental vaccine, developed by Fauci’s colleagues at the National Institutes of Health and Moderna Inc., will start its most important step around July 27: A 30,000-person study to prove if the shots really are strong enough to protect against the coronavirus.

[The 45] early volunteers developed what are called neutralizing antibodies in their bloodstream — molecules key to blocking infection — at levels comparable to those found in people who survived COVID-19…

There’s no guarantee but the government hopes to have results around the end of the year — record-setting speed for developing a vaccine.

The vaccine requires two doses, a month apart.

The NIH-developed shot isn’t the only one set for such massive U.S. testing, crucial to spot rare side effects. The government plans similar large studies of the Oxford candidate and another by Johnson & Johnson; separately, Pfizer Inc. is planning its own huge study.

People think “this is a race for one winner. Me, I’m cheering every one of them on,” said Fauci, who directs NIH’s National Institute of Allergy and Infectious Diseases. “We need multiple vaccines. We need vaccines for the world, not only for our own country.”

MacDailyNews Take: 🤞🏻

9 Comments

  1. The big problem is how long immunity lasts. Recent evidence indicates that immunity from infection varies between those who are mildly affected end up with fewer antibodies and less protection than those who are severely affected who end up with a higher level of antibodies and thus a higher level of protection.

    What then complicates matters is that the antibody levels decline over time. It’s kind of like getting a cold and then you get another cold. Alternatively, you get the flu and then some time later you need another vaccine to protect yo against the same strain of influenza.

    However this virus is NOT like the flu and is much, much worse than a cold. This is the virus from hell.

    For an explanation on the different categories of vaccines just click on the following link.

    https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-vaccine/art-20484859

  2. Good news, though generating antibodies is one thing, reports of antibodies not being sustained for very long in recovered patients (possibly as little as a month or so) doesn’t sound so good. Especially as vaccines generally would struggle to produce the initial spike in antibodies that having the actual disease would produce, thus the double dose of the vaccine. Of course antibodies are not the only defence, T-Cells being another suspected defender in similar viruses and it will be interesting to see if the vaccines encourage these other defences to develop as they may be important in long term protection (be it first or another infection) be it prevention or as a dampening down of any further infection.

    1. BoyJah, from its inception, MDN has been at least as much about AAPL the stock as about Apple the company. Stocks are dependent on the economy. AAPL’s growth potential will be limited if few people have discretionary spending capacity due to a severe recession. Happy Talk from Washington notwithstanding, COVID-19 is a mortal threat not only to human health but economic health. Realistically, we will keep cycling between opening up and shutting down until a vaccine is widely distributed. So that is what a vaccine has to do with Apple and its products.

  3. Science increasingly shows that COVID-19 is a relatively minor threat to human beings. It is not the disease itself but the indefensible response to this perceived threat that is the real threat. A vaccine will do nothing to change that. But more importantly, it has NOTHING to do with Apple products or services. NOTHING

  4. The same scientists who say COVID-19 is a minor threat say that the earth is flat. In less than six months, it has killed as many Americans as World War I, Korea, and Vietnam combined did over twenty-odd years (excluding flu deaths from WW I). None of those seemed very minor at the time.

    1. I would be very interested to know which scientists specifically you are referring to and where I can see the undeniable, statistically provable number of deaths to which you are referring. I really want to know, as I am more than willing to modify my opinion based on pure facts and data! After learning that many deaths have been incorrectly associated with COVID-19, I have become skeptical of undocumented death toll numbers.

      1. After learning of the Antarctic ice wall, I have become skeptical of the Earth’s curvature.

        The claims that the death toll is inflated are baseless. If anything, the death toll has been underestimated.

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