Apple has released Tunes Repair Tool for Vista 1.0 which will repair permissions for important files required by iTunes to play your iTunes Store purchases.
Basically, some Vista sufferers found that they couldn’t play their iTunes-purchased songs after “upgrading” to Windows Vista. This tool corrects the permissions issue.
Just to be clear: Tunes Repair Tool for Vista 1.0 is not for Mac users.
As for other issues with Vista and iTunes, “Apple recommends that customers wait to upgrade Windows until after the next release of iTunes which will be available in the next few weeks.”
More info and download link (88KB) here.
[Thanks to MacDailyNews Reader “Adam W.” for the heads up.]